Zhouwei and Netta studied synchronous primary ileal neuroendocrine tumors (NETs) to identify recurrent copy-number alterations. They confirmed that chromosome (chr) 18 loss of heterozygosity (LOH) is the most common copy-number alteration. Interestingly, they identified three different chr18 LOH patterns in different tumors from the same patients. These different chr18 LOH patterns suggest that synchronous primary ileal NETs are likely to develop independently, via a mechanism that is not currently understood.
Finally back to our news feature on the website. (I just learned how to do this myself and will do more frequent updates... getting more techy!)
Just published in Cancer Cell: Alison Taylor's work on cancer aneuploidy, delineating aneuploidy as the most common alteration in cancer genomes and showing genomic and functional correlates of aneuploidy, working with Gavin Ha, Galen Gao, Andy Cherniack, Rameen Beroukhim and TCGA friends. Plus, Alison developed, together with Peter Choi, a beautiful method to generate aneuploid chromosomes using genome engineering (in this case, chopping off 3p using CRISPR to build cellular models of 3p loss or of 3q gain). If you are a university hiring faculty, and want to recruit a scientist who is willing to tackle tough and important scientific problems with tenacity, keep an eye out for Alison!
Also, out today, Ashton Berger as lead author from our group (with TCGA folks and many others, but without me as an author) led the pan-cancer analysis of the genomes of breast and gynecological cancers. Great work! Ashton is a computational biologist just a couple years out of undergrad studies at UT Austin. Grad schools and biotechs, keep an eye out for Ashton!
More to come in this space soon...
A big welcome to Donna Fonfara and Jian Carrot-Zhang who recently joined the lab. Donna is a graduate student from Utrecht University, the Netherlands, who will be pursuing her PhD in the Meyerson laboratory, while Jian is a research fellow joining us from McGill University in Montreal, Canada, from where she graduated with a PhD in Human Genetics and Bioinformatics.
Welcome to the laboratory and to Boston, Donna and Jian!
Peter Choi was recently awarded a K99/R00 "Pathway to Independence" Award from the National Cancer Institute to support his research on the role of mutations in the RNA splicing regulator, RBM10, in cancer.
The award begins July 1, 2016. Well done, Peter, and congratulations!
The Van Andel Research Institute conferred the 2016 Han-Mo Koo Memorial Award on Matthew Meyerson, for his significant contributions to cancer genomics research and its translation to targeted therapies.
Previous winners have included Drs. Eric Lander, Frank McCormick and Phillip Sharp.
Want to know more about the Han-Mo Koo Memorial Award? Click HERE or visit the Van Andel Research Institute's Facebook page.
The recovery of Ronaldo De Oliveira: a demonstration of the power of genomic analysis of tumors in cancer treatment. Matthew Meyerson weighs in.
Click HERE for article in US News and World Report
Amy Blum of the National Cancer Institute interviewed Dr. Meyerson on his work and the future of cancer genomics.
Matthew Meyerson was awarded a prestigious Outstanding Investigator Award (R35 grant) from the National Cancer Institute, effective August 2015 through June 2022. He is one of about 40 scientists nationwide to receive this 7-year research grant, in recognition of his groundbreaking contributions to lung cancer research and of the potential of his research program to continue to engineer genomics-driven breakthroughs in lung cancer biology.
Alice Berger, Research Fellow, was awarded a highly competitive K99/R00 "Pathway to Independence" Award from the National Cancer Institute. The K99/R00 award is given to outstanding fellows with less than 5 years of postdoctoral research training, to encourage their transition to independent academic positions.
Alice's application, on illuminating the role of a recently identified oncogene in lung adenocarcinoma, the small GTPase protein, RIT1, received a score of "10", the highest possible score....congratulations, Alice!!