In vitro models of aneuploidy.
Taylor, et al., Cancer Cell, 2018. Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
Taylor, et al., Cancer Cell, 2018. Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
Lung Cancer Biology
Our research moves from genome discovery into the functional analysis of lung cancer genome alterations.
Areas of interest include aneuploidy, EGFR structure and function, structure and function of amplified genes such as NKX2-1, and analysis of novel lung cancer genes including the splicing factor U2AF1 and the RNA modifier CMTR2.
For aneuploidy, we developed a recombination-directed approach to generate chromosome aneuploidy and used this method to remove one copy of the chromosome arm 3p in human lung epithelial cells (Taylor, et al., 2018). Follow up analysis of aneuploidy has revealed fitness effects of aneuploidy in the cancer genome and a specific role for loss of chromosome 8p (Shih et al., 2023).
Watch this space for more news on some of the lung cancer genes—coming soon!
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Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
John L. Pulice, Matthew Meyerson
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Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers
Xiaoyang Zhang, Peter S Choi, Joshua M Francis, Marcin Imielinski, Hideo Watanabe, Andrew D Cherniack, Matthew Meyerson
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EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
J Guillermo Paez, Pasi A Jänne, Jeffrey C Lee, Sean Tracy, Heidi Greulich, Stacey Gabriel, Paula Herman, Frederic J Kaye, Neal Lindeman, Titus J Boggon, Katsuhiko Naoki, Hidefumi Sasaki, Yoshitaka Fujii, Michael J Eck, William R Sellers, Bruce E Johnson, Matthew Meyerson
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Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
John L. Pulice, Matthew Meyerson
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An essential role for Cmtr2 in mammalian embryonic development
Alena V Yermalovich, Zarin Mohsenin, Mitzy Cowdin, Bruno Giotti, Akansha Gupta, Alice Feng, Lior Golomb, Douglas B Wheeler, Kelly Xu, Alexander Tsankov, Ondine Cleaver, Matthew Meyerson
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XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
Tao Zou, Meng Zhou, Akansha Gupta, Patrick Zhuang, Alyssa R Fishbein, Hope Y Wei, Diego Capcha-Rodriguez, Zhouwei Zhang, Andrew D Cherniack, Matthew Meyerson
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