The current focus areas for the Meyerson laboratory include lung cancer genomics and biology, the non-coding cancer genome, the cancer microbiome, and genome-inspired cancer drug discovery. Current projects in the lab include:
Lung cancer is the leading cause of cancer death in the United States and worldwide. The Meyerson laboratory has focused on understanding lung cancer biology by interrogating the lung cancer genome. Over the past decades, Dr. Meyerson and colleagues have discovered genes and gene alterations important in human cancer, including
- Human cyclin-dependent kinase family including CDK2 and CDK6
- The human telomerase catalytic subunit gene TERT
- Somatic mutations in lung cancer in EGFR, U2AF1, RBM10, HLA genes and others
- Copy number alterations including lineage amplifications of SOX2 and NKX2-1 in lung cancers.
- The biology and translational potential of cancer aneuploidy.