In vitro models of aneuploidy.
Taylor, et al., Cancer Cell, 2018. Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Lung Cancer Biology

Our research moves from genome discovery into the functional analysis of lung cancer genome alterations.

Areas of interest include aneuploidy, EGFR structure and function, structure and function of amplified genes such as NKX2-1, and analysis of novel lung cancer genes including the splicing factor U2AF1 and the RNA modifier CMTR2.

For aneuploidy, we developed a recombination-directed approach to generate chromosome aneuploidy and used this method to remove one copy of the chromosome arm 3p in human lung epithelial cells (Taylor, et al., 2018). Follow up analysis of aneuploidy has revealed fitness effects of aneuploidy in the cancer genome and a specific role for loss of chromosome 8p (Shih et al., 2023).
 
Watch this space for more news on some of the lung cancer genes—coming soon!


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